Abstract: Against the background of health big data, how to effectively protect the safety of patients' medical data and reduce and eliminate privacy leakage is an important issue that needs to be considered and studied at present. This paper investigates patients' awareness of privacy protection, whether there is privacy leakage and impact, awareness and measures of medical information protection in Anhui Province through questionnaires, aiming to provide more targeted data sharing and privacy protection basis for health big data analysis. The survey found that patients have a high awareness of privacy protection, and the respondents are willing to share medical information, but they are worried about privacy leakage. Privacy leakage often exists and has an impact on the relevant parties and the respondents have little understanding, use or trust of related laws and regulations. In the era of health big data, patient privacy protection needs the joint efforts of the government, individuals and medical institutions at all levels.

Key words: health big data, privacy protection, awareness, ethics