巢湖学院学报 ›› 2019, Vol. 21 ›› Issue (6): 102-109.doi: 10.12152/j.issn.1672-2868.2019.06.015

• 化学与材料科学 • 上一篇    下一篇

黄芪多糖胶囊壳的制备及质量评价

巢湖学院 化学与材料工程学院,安徽 巢湖238000   

  1. 1.巢湖学院 化学与材料工程学院,安徽 巢湖  238000;2.巢湖今辰药业有限公司,安徽  巢湖 238000
  • 收稿日期:2019-07-08 出版日期:2019-11-25 发布日期:2020-03-13
  • 通讯作者: 朱双双(1990-),女,安徽淮南人,巢湖学院化学与材料工程学院助教,主要从事药物新剂型及新制剂研究。
  • 作者简介:朱双双(1990-),女,安徽淮南人,巢湖学院化学与材料工程学院助教,主要从事药物新剂型及新制剂研究。
  • 基金资助:
    巢湖学院自然科学一般项目(项目编号:XLY-201809);安徽省大学生创新创业训练计划项目(项目编号:AH201810380029)

Preparation and Quality Evaluation of Astragalus Polysaccharide Capsule Shell

1.School of Chemistry and Material Engineering, Chaohu University, Chaohu Anhui 238000; 2. Chaohu Jinchen Pharmaceutical Company Limited, Chaohu Anhui 238000#br#   

  1. 1.School of Chemistry and Material Engineering, Chaohu University, Chaohu Anhui 238000; 2. Chaohu Jinchen Pharmaceutical Company Limited, Chaohu Anhui 238000
  • Received:2019-07-08 Online:2019-11-25 Published:2020-03-13
  • Contact: ZHU Shuang-shuang:1. School of Chemistry and Material Engineering, Chaohu University, Chaohu Anhui 238000; 2. Chaohu Jinchen Pharmaceutical Company Limited, Chaohu Anhui 238000
  • About author:ZHU Shuang-shuang:1. School of Chemistry and Material Engineering, Chaohu University, Chaohu Anhui 238000; 2. Chaohu Jinchen Pharmaceutical Company Limited, Chaohu Anhui 238000
  • Supported by:
    XLY-201809;AH201810380029

摘要: 植物型胶囊壳可克服市售明胶胶囊壳的诸多缺点,例如失水硬化、吸水软化、来源难控、患者依从性差等,具有良好的发展前景。研究以黄芪多糖为成膜材料制备植物多糖胶囊壳,并进行质量评价。以黄芪多糖游离膜透湿性、胶囊壳成囊性为评价指标,通过单因素实验及正交设计实验考察黄芪多糖质量、羟丙基甲基纤维素种类、羟丙基甲基纤维素质量、甘油体积对黄芪多糖胶囊壳的影响,并进行脆碎度尧松紧度、体外释放度评价。根据数据得到黄芪多糖胶囊壳的最优处方为黄芪多糖0.75 g,羟丙基甲基纤维素种类为150000 mPa?s,羟丙基甲基纤维素1.3 g,甘油体积2.0 mL,在此条件下制备的黄芪多糖游离膜透湿系数为0.005 g?mm?m-2?h-1?kPa-1,透湿性低,胶囊壳成囊性评分为11 分,成囊性好,且自制的胶囊壳脆碎度、松紧度符合药典要求,体外释放实验表明其具有缓释作用。

关键词: 多糖胶囊壳, 处方优化, 质量评价

Abstract: The plant-type capsule shell can overcome many shortcomings of the commercially available gelatin capsule shell, such as water-resistance hardening, water absorption softening, difficult source control, poor patient compliance, etc., and has a good development prospect. In this experiment, plant polysaccharide capsule shells were prepared by using Astragalus polysaccharide as a film-forming material, and quality evaluation was carried out.Taking the moisture permeability of the free film of Astragalus polysaccharide and the cysticity of capsule shell as the evaluation index, the quality of Astragalus polysaccharide, the type of hydroxypropyl methylcellulose, the quality of hydroxypropyl methylcellulose, glycerin and the effect of volume on the capsule shell of Astragalus polysaccharides were investigated by single factor experiment and orthogonal design experiment; friability, tightness and in vitro release were evaluated. According to the data, the optimal prescription of Astragalus polysaccharide capsule shell
is 0.75 g of Astragalus polysaccharide, 150,000 mPa?s of hydroxypropyl methylcellulose, 1.3 g of hydroxypropyl methylcellulose, 2.0 mL of glycerol, and homemade capsule shell. The friability and tightness meet the requirements of the pharmacopoeia; the moisture permeability of the free film of Astragalus polysaccharide prepared under these conditions is g?mmm-2?h-1?kPa-1, which is low; the capsule shell has a cystic score of 11 points, so the cysticity is good. The self-made capsule shell has the friability and tightness in accordance with the requirements of the pharmacopoeia, and the in vitro release test shows that it has a sustained release effect.

Key words: Polysaccharide capsule shell, prescription optimization, quality evaluation

中图分类号: 

  • R93