In the early days of the People's Republic of China, various diseases, including malaria, were rampant in Guangxi, posing a serious threat to the health of local people, and affecting Guangxi's economic and social development and people's livelihoods. Under the correct leadership of the Party and the government, the central health administration department formulated scientific and effective epidemic prevention measures and gave special guidance to provinces with severe malaria epidemics. Under the guidance of the central policy on health and epidemic prevention, on the basis of the epidemiological investigation of malaria, Guangxi formulated prevention and control plans, established epidemic prevention institutions, trained medical personnel, adopted comprehensive prevention and control measures, and carried out health publicity as well as education on malaria prevention and control to the general public, in an effort to fundamentally control and eliminate the spread of malaria. After active prevention and control, certain achievements were made in malaria control in Guangxi, and experience was accumulated for malaria control in the future.