The local expression of the rural memorial hall can help promote rural culture, and it is an important part of the local cultural gene translation from the perspective of regional culture. Based on the literature analysis and field investigation of the regional culture of Liu Mingchuan's hometown, this paper uses the method of landscape gene translation to do the design analysis and elaboration. Combined with the Liu Mingchuan Memorial Hall designed by Anhui Urban Construction Design and Research Institute, the design overview is analyzed from three angles: design conception, architectural form and spatial layout. At the same time, three design interpretations are proposed based on the above analysis: design translation expresses the local landscape genes; architecture is integrated in the geographical topography; space conveys the spirit of the times. This provides reference for the construction of rural memorial buildings with regional characteristics and the spirit of the times.