The paper takes China-Chile Free Trade Zone as an example to explore how China can build a highquality free trade zone with foreign countries under the regular epidemic prevention and control, and achieve winwin cooperation. Based on the quantitative description of China-Chile Free Trade Zone, the trade complementary index is used to find that China-Chile bilateral products are highly complementary, and China mainly exports products with low added value to Chile. The epidemic has a great impact on the complementarity of Chinese exports. The synthetic control method is also adopted to prove that the construction of free trade zone has indeed driven the growth of China-Chile trade flow, affirming that the establishment of free trade zone has a positive effect on the sustainable development of China's foreign trade. Finally, according to the research results, some suggestions are put forward for the development of China爷s foreign free trade zone under regular epidemic prevention and control.