This paper analyzes the impact of digital economy on the integration of traditional cultural industry and tourism in Chaohu Lake area from 2012 to 2019 based on coupling coordination degree model, and introduces social network analysis method to explore the moderating effect of economic network centrality. The results show that the integration degree of traditional cultural industry and tourism is increasing in recent years; Hefei enjoys the best performance, followed by Chaohu city, Feidong county, Changfeng county, Feixi county and Lujiang county. The development of digital economy significantly promotes the integration of traditional cultural industries and tourism; the digital economy network, tourism economy network and traditional culture economy network all present "core-edge" structure, but the density is low. The Hefei municipal district is in the core position in the three networks. The centrality of the three networks positively regulates the impact of digital economy on the integration of traditional cultural industry and tourism. Finally, policy suggestions are put forward on promoting the development of digital economy, strengthening the penetration of digital technology in traditional cultural industry and tourism, and strengthening the economic ties between regions.