The smooth progress of the "the Belt and Road Initiative" provides a great strategic opportunity for the internationalization development of China's higher education. Designing a targeted, feasible and innovative international talent training plan for overseas students in China is an important measure to promote the internationalization development of colleges and universities. Based on the analysis of talent demand and characteristics of countries along the route of "the Belt and Road", this paper thinks about the curriculum and talent training mode for overseas students from the countries along "the Belt and Road". By establishing the "Four in One" curriculum and the" Three Stages and Seven Modules" talent training mode, the design of the curriculum is innovated, the channels of talent training are broadened, and the quality and level of training overseas students are improved.