The concept of Outcome-Based Education（OBE） has been highly valued and recognized in higher education, and has profoundly affected the reform of courses in universities. In application-oriented universities, there are some common problems concerning the teaching of the Business English core courses, namely, an unclear course orientation, the selection of badly-targeted textbooks, and a monotonous teaching methodology. In the context of developing high-level application-oriented universities, all should start with OBE by analyzing the current situation of the Business English core courses, defining clearly the reform ideas, clarifying the course orientation, rationally selecting the teaching material, attaching importance to students participation, and strengthening the building of faculty, so as to find the right path for the reform.