The Great Learning is rich in the thought of inner-wisdom and outer-practice, which mainly emphasizes the learning of inner-wisdom to achieve self-reliance, and the learning of outer-practice to be helpful for others, and develops as a systematic way of self-cultivation, family regulation and state rule. Combining with the characteristics of the times and the needs of social development, we apply the basic principles of Marxism to the modern transformation of the thought of inner-wisdom and outer-practice in The Great Learning, and endue it with new connotations and forms of expression and give it new vitality. On this basis, we have taken the initiative to draw on some of the beneficial thoughts that play an enlightening role in fostering virtue through education in the new era, such as cultivating one's moral character, self-reliance and helpfulness, and the unity of knowledge and action, and make the good traditional culture of China become the spirit of the new era.