In view of the fact that ideological and political teaching and innovation and entrepreneurship education have many commonalities in objectives, contents, forms, time and space, we can integrate innovation and entrepreneurship education into ideological and political teaching to solve the "two skins" problem of them. However, the academic research on this issue still has significant deficiencies. In order to meet the practical needs of ideological and political education reform and innovation in universities, we should sort out the internal connection between them and build an operating mechanism that takes goal integrating as the command, content integrating as the core, form integrating as the key, and time and space integrating as the guarantee.