Bioengineering equipment and factory design is a compulsory course for bioengineering majors. In view of the professional, practical and comprehensive qualities of the content, and the lack of factory practice for the students, it is hard to teach and learn the curriculum knowledge. In order to let the students master the curriculum knowledge better, the teaching content, teaching methods and assessment methods were reformed and carried out in practice. The results showed that the reform measures can effectively improve the course teaching effect, and most of students are satisfied with reform measures.