基于2015—2020年安徽省16个市级面板数据，运用层次分析-熵权法构建了区域创新评价体系，以区位熵表征高技术产业集聚水平，然后实证分析了区域创新体系与高技术产业集聚间的互动关系。结果表明，安徽省区域间高技术产业集聚度差异与区域创新体系综合得分差异的变化趋势总体一致，两者之间存在格兰杰因果关系，并且呈现出以合肥市、芜湖市为中心向南北圈层递减的空间分布特征；安徽省高技术产业集聚发展过程中存在较为显著的“滚雪球效应”；区域创新体系对高技术产业集聚水平的促进作用比单一指标更为明显；外商直接投资、科研经费投入和经济发展水平均对高技术产业集聚具有显著正向影响作用，但由于苏、浙、沪对安徽省高层次科技创新人才的虹吸效应以及科技创新人才结构趋于异质化，导致科研人员投入暂时还无法发挥对高技术产业集聚发展的正向促进作用。

Based on 16 municipal panel data of Anhui Province from 2015 to 2020, this paper uses the hierarchical analysis—entropy weight method to construct a regional innovation evaluation system, characterizes the level of high-tech industry agglomeration by location entropy, and then empirically analyzes the interaction between regional innovation system and high-tech industry agglomeration. The results show that: the differences in the trends of the concentration of high-tech industries and the differences in the comprehensive scores of regional innovation systems in Anhui Province are generally consistent, and there is a Granger causality relationship between the two; the spatial distribution characteristic is a decreasing trend in the north-south circle with Hefei and Wuhu as the centre; there is a significant "snowball effect" in the development of high-tech industry agglomeration in Anhui Province; the regional innovation system has a more obvious role in promoting the level of high-tech industry agglomeration than a single indicator; foreign direct investment, the investment in scientific research and the level of economic development all have significant positive effects on high-tech industry agglomeration; but due to the siphoning effect of Jiangsu Province, Zhejiang Province and Shanghai on high-level scientific and technological innovation talents in Anhui Province and the tendency towards the heterogeneous structure of scientific and technological innovation talents, the investment in scientific research personnel cannot play a positive role in promoting the high-tech industry agglomeration for the time being.