环境中磺胺类抗生素污染的快速检测对水环境监测及治理具有重要作用。分别以掺氮碳量子点、3-氨基丙基三乙氧基硅烷、乙二醇二甲基丙烯酸酯和磺胺甲基嘧啶为荧光源、功能单体、交联剂和模板分子，制备了对磺胺甲基嘧啶具有识别性的碳点基分子印迹荧光传感器（CQDs-MIP）。通过吸附实验，考察了功能单体添加量、溶剂种类和交联剂类型对CQDs-MIP性能的影响。实验结果表明，CQDs-MIP对磺胺甲基嘧啶的吸附过程符合Langmuir吸附等温模型和拟二阶动力学方程，并对磺胺甲基嘧啶具有高选择性，相对于磺胺嘧啶和磺胺二甲基嘧啶的选择性系数分别为2.28及3.02；在最优检测条件下，CQDs-MIP对磺胺甲基嘧啶的响应线性范围为2~100 mg·L^-1，线性相关系数R² = 0.9972；CQDs-MIP具有快速、灵敏地检测磺胺甲基嘧啶的能力。

Rapid detection of sulphonamide antibiotic contamination in the environment is important for water environment monitoring and management. To fabricate carbon quantum dots based fluorescent molecularly imprinted sensor（CQDs-MIP） with specific recognition ability for sulfamethazine, nitrogen-doped carbon quantum dots, 3-aminopropyltriethoxysilane, ethylene glycol dimethacrylate and sulfamethazine were used as the fluorescence source, functional monomer, cross-linker and template molecule respectively. The effects of functional monomer addition, solvent type and cross-linker type on the performance of CQDs-MIP were investigated by adsorption experiments. The experimental results showed that the adsorption process of CQDs-MIP on sulfamethazine was in accordance with the Langmuir adsorption isotherm model and the second-order kinetic equation, and showed high selectivity for sulfamethazine with the selectivity coefficients of 2.28 and 3.02 with respect to sulfadiazine and sulfadimethazine, respectively. The linear range of CQDs-MIP for sulfamethazine was 2~100 mg·L^-1 with a linear correlation coefficient of R² = 0.9972; CQDs-MIP has the ability to detect sulfamethazine rapidly and sensitively.